POLR2F

Across TCGA pan-cancer cohorts, POLR2F RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated POLR2F data layer compared with 1 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher POLR2F RNA is associated with worse overall survival. In most high-consensus cancer types, elevated POLR2F expression acts as an unfavorable survival marker, although some lineages such as LUAD and LGG show a favorable association.

COAD, KIRC, and ACC are the cancer types where POLR2F RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	OS	Quartile	IV	0.237	0.792	<.001	114	view →
KIRC	DFS	Median	All	0.554	0.686	.001	67	view →
ACC	DFS	Tertile	All	0.208	0.755	<.001	61	view →
LUAD	OS	Tertile	All	0.451	0.190	.005	30	view →
LGG	OS	Tertile	All	0.493	0.346	<.001	30	view →
ESCA	OS	Median	All	0.677	0.442	.001	27	view →
BRCA	DFS	Median	IV	0.285	0.732	.001	20	view →
SARC	DFS	Tertile	All	0.661	0.366	.002	18	view →
LUSC	DFS	Tertile	III,IV	0.203	0.853	<.001	18	view →
READ	OS	Median	III,IV	0.813	0.277	<.001	16	view →
SCLC	OS	Median	III,IV	0.757	0.460	.010	16	view →
KIRP	DFS	Quartile	III,IV	0.139	0.579	.003	13	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

POLR2F–COAD (OS)

Open the COAD breakdown →