POLR2F

Across TCGA pan-cancer cohorts, POLR2F RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of POLR2F’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where POLR2F RNA is more highly expressed in tumor relative to normal tissue. In most cancer types POLR2F is over-expressed in tumor, although a few such as UCEC and COAD show the opposite, repressed pattern.

KIRC, UCEC, and COAD are the cancer types where POLR2F tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in POLR2F RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	II,III,IV	+0.103	<.001	11	view →
UCEC	All	All	−0.253	<.001	8	view →
COAD	Male	All	−0.067	<.001	8	view →
BRCA	Female	II,III,IV	−0.523	<.001	6	view →
BLCA	All	IV	−0.160	<.001	6	view →
CHOL	All	All	+0.133	<.001	5	view →
HNSC	All	II,III,IV	−0.125	.012	4	view →
LUAD	Male	III,IV	−0.053	.006	3	view →
READ	All	All	−0.123	.024	2	view →
PRAD	All	All	−0.082	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

POLR2F–KIRC

Open the KIRC breakdown →