POLR2F

Across TCGA patient cohorts, POLR2F mutation is significantly associated with the total protein of many other genes, with 14 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible POLR2F-associated genes across cancer lineages are A-Raf_pS299, Heregulin, and Myosin-IIa_pS1943. Each is linked with POLR2F in more than 1 cancer types. Because this analysis shows association rather than direction, both POLR2F-to-partner and partner-to-POLR2F results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, A-Raf_pS299 grouped by POLR2F-low versus POLR2F-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (POLR2F→partner) and Y-score (partner→POLR2F) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	A-Raf_pS299 →	-0.140	-3.000	.020	.036	3	1
UCEC	Heregulin →	-0.124	-2.986	.044	.035	3	1
UCEC	Myosin-IIa_pS1943 →	+0.299	+2.335	.003	.020	3	1
UCEC	Notch1 →	+0.245	+2.820	<.001	.035	3	1
UCEC	p62 Lck ligand →	+0.383	+2.331	.019	.019	3	1
UCEC	Annexin-1 →	+0.761	+3.189	.003	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

A-Raf_pS299 by POLR2F expression — UCEC

Explore this box plot interactively →