POLR2F

Across TCGA cell cohorts, POLR2F RNA expression is significantly associated with the go_rna of many other GO terms, with 3,883 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible POLR2F-associated GO terms across cancer lineages are Termination of RNA polymerase III transcription, [2Fe-2S] cluster assembly, and Positive regulation of mitochondrial translation. Each is linked with POLR2F in more than 14 cancer types. Because this analysis shows association rather than direction, both POLR2F-to-partner and partner-to-POLR2F results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Termination of RNA polymerase III transcription grouped by POLR2F-low versus POLR2F-high in SKIN.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (POLR2F→partner) and Y-score (partner→POLR2F) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	Termination of RNA polymerase III transcription →	+0.130	+1.065	<.001	<.001	3	15
CNS	[2Fe-2S] cluster assembly →	+0.104	+0.808	<.001	<.001	3	13
PANCREAS	Positive regulation of mitochondrial translation →	+0.090	+0.676	.001	<.001	3	12
UPPER_AERODIGESTIVE_TRACT	Double-strand break repair via break-induced replication →	+0.199	+0.765	.001	<.001	3	12
BLOOD_Lymphoma	[4Fe-4S] cluster assembly →	+0.128	+0.694	<.001	<.001	3	11
BLOOD_Myeloma	DNA replication initiation →	+0.175	+1.020	<.001	.002	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,883 associations by consensus.

Termination of RNA polymerase III transcription by POLR2F expression — SKIN

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