POLR2C

Across TCGA cell cohorts, POLR2C RNA expression is significantly associated with the go_rna of many other GO terms, with 3,745 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible POLR2C-associated GO terms across cancer lineages are Protein localization to chromosome, snRNA processing, and Transcription initiation at RNA polymerase II promoter. Each is linked with POLR2C in more than 13 cancer types. Because this analysis shows association rather than direction, both POLR2C-to-partner and partner-to-POLR2C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Protein localization to chromosome grouped by POLR2C-low versus POLR2C-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (POLR2C→partner) and Y-score (partner→POLR2C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Protein localization to chromosome →	+0.124	+0.894	.001	.003	3	14
LUNG_NSCLC_LUSC	snRNA processing →	+0.109	+0.888	.006	.007	2	14
UPPER_AERODIGESTIVE_TRACT	Transcription initiation at RNA polymerase II promoter →	+0.071	+0.735	<.001	<.001	3	12
BLOOD_Lymphoma	Establishment of protein localization to organelle →	+0.042	+0.682	<.001	<.001	3	12
UPPER_AERODIGESTIVE_TRACT	Double-strand break repair via break-induced replication →	+0.226	+1.003	.003	<.001	3	11
LUNG_NSCLC_LUSC	snRNA 3'-end processing →	+0.109	+0.882	.003	.002	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,745 associations by consensus.

Protein localization to chromosome by POLR2C expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →