POLR2C

Across TCGA pan-cancer cohorts, POLR2C RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated POLR2C data layer compared with 3 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher POLR2C RNA is associated with worse overall survival. In most high-consensus cancer types, elevated POLR2C expression acts as an unfavorable survival marker, although some lineages such as KIRC and LUAD show a favorable association.

HNSC, KIRC, and LGG are the cancer types where POLR2C RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Tertile	All	0.250	0.455	<.001	121	view →
KIRC	OS	Median	All	0.716	0.539	<.001	112	view →
LGG	OS	Median	All	0.367	0.534	<.001	51	view →
LUAD	DFS	Median	IV	0.843	0.240	.001	27	view →
CESC	DFS	Quartile	All	0.388	0.656	.005	26	view →
BLCA	OS	Median	All	0.479	0.705	.010	24	view →
ACC	DFS	Median	III,IV	0.595	0.098	<.001	17	view →
LAML	DFS	Quartile	All	0.441	0.713	.008	16	view →
THCA	DFS	Tertile	IV	0.706	0.980	.019	13	view →
UVM	OS	Median	III,IV	0.288	1.000	.004	12	view →
STAD	OS	Median	II,III,IV	0.607	0.791	.019	12	view →
ESCA	OS	Quartile	III,IV	0.279	0.528	.034	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

POLR2C–HNSC (OS)

Open the HNSC breakdown →