POLR2C

Across TCGA pan-cancer cohorts, POLR2C RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of POLR2C’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where POLR2C RNA is more highly expressed in tumor relative to normal tissue. In most cancer types POLR2C is over-expressed in tumor, although a few such as KICH and THCA show the opposite, repressed pattern.

HNSC, COAD, and KIRC are the cancer types where POLR2C tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in POLR2C RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	III,IV	+0.724	<.001	12	view →
COAD	Female	II,III,IV	+0.833	<.001	11	view →
KIRC	Female	All	+0.608	<.001	11	view →
KICH	Male	All	−0.884	<.001	10	view →
LIHC	All	All	+0.555	<.001	7	view →
THCA	All	IV	−0.402	.003	6	view →
CHOL	Male	All	+1.316	<.001	4	view →
STAD	Male	II,III,IV	+0.613	<.001	4	view →
ESCA	All	All	+0.631	.009	3	view →
LUSC	Female	II,III,IV	−0.402	.009	3	view →
KIRP	All	II,III,IV	+0.341	.019	2	view →
PRAD	All	All	−0.249	.013	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

POLR2C–HNSC

Open the HNSC breakdown →