POLR2A

Across TCGA patient cohorts, POLR2A mutation is significantly associated with the RNA expression of many other genes, with 5,810 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible POLR2A-associated genes across cancer lineages are RCC1, CCNB1, and CDKN3. Each is linked with POLR2A in more than 4 cancer types. Because this analysis shows association rather than direction, both POLR2A-to-partner and partner-to-POLR2A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RCC1 grouped by POLR2A-low versus POLR2A-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (POLR2A→partner) and Y-score (partner→POLR2A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	RCC1 →	+0.586	+3.183	<.001	.009	3	5
UCEC	CCNB1 →	+0.610	+1.917	<.001	<.001	3	5
UCEC	CDKN3 →	+0.691	+1.928	<.001	<.001	3	4
COAD	MTFMT →	+0.419	+3.611	.002	.001	3	4
COAD	RFC5 →	+0.513	+3.611	<.001	.001	3	4
COAD	KIF20A →	+0.561	+3.196	.001	.009	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,810 associations by consensus.

RCC1 by POLR2A expression — COAD

Explore this box plot interactively →