POLR2A

Across TCGA cell cohorts, POLR2A mutation is significantly associated with the RNA expression of many other genes, with 1,407 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible POLR2A-associated genes across cancer lineages are STYX, NISCH, and FAM149A. Each is linked with POLR2A in more than 2 cancer types. Because this analysis shows association rather than direction, both POLR2A-to-partner and partner-to-POLR2A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, STYX grouped by POLR2A-low versus POLR2A-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (POLR2A→partner) and Y-score (partner→POLR2A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	STYX →	+0.592	+3.850	.001	<.001	3	3
LARGE_INTESTINE	NISCH →	+0.832	+3.850	<.001	<.001	3	2
LARGE_INTESTINE	FAM149A →	+1.134	+3.389	.001	.001	3	2
LARGE_INTESTINE	RIC8B →	+0.456	+2.743	.004	.001	3	2
LARGE_INTESTINE	SIPA1L2 →	+1.190	+2.743	.002	.001	3	2
LARGE_INTESTINE	ACADM →	+0.595	+2.743	.007	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,407 associations by consensus.

STYX by POLR2A expression — LARGE_INTESTINE

Explore this box plot interactively →