POLR1F

Across TCGA cell cohorts, POLR1F mutation is significantly associated with the RNA expression of many other genes, with 6 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible POLR1F-associated genes across cancer lineages are LMNTD1, KRTAP10-6, and TBL1Y. Each is linked with POLR1F in more than 1 cancer types. Because this analysis shows association rather than direction, both POLR1F-to-partner and partner-to-POLR1F results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LMNTD1 grouped by POLR1F-low versus POLR1F-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (POLR1F→partner) and Y-score (partner→POLR1F) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	LMNTD1 →	+0.250	+3.969	<.001	.002	3	1
LARGE_INTESTINE	KRTAP10-6 →	+0.036	+3.347	.001	.005	3	1
LARGE_INTESTINE	TBL1Y →	+0.131	+3.632	<.001	.003	3	1
SKIN	KRTAP5-4 →	+0.101	+4.977	<.001	.007	3	1
LUNG_NSCLC_LUAD	PRAMEF14 →	+0.012	+5.662	<.001	.002	3	1
LUNG_NSCLC_LUAD	CXorf51B →	+2.602	+5.228	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

LMNTD1 by POLR1F expression — LARGE_INTESTINE

Explore this box plot interactively →