POLR1F

Across TCGA pan-cancer cohorts, POLR1F RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of POLR1F’s most consistent transcriptional readouts.

The strongest signal is observed in stomach adenocarcinoma (STAD), where POLR1F RNA is more highly expressed in tumor relative to normal tissue. In most cancer types POLR1F is over-expressed in tumor, although a few such as THCA and UCEC show the opposite, repressed pattern.

STAD, COAD, and HNSC are the cancer types where POLR1F tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in POLR1F RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
STAD	Male	II,III,IV	+1.015	<.001	9	view →
COAD	Male	All	+0.929	<.001	9	view →
HNSC	All	IV	+0.792	<.001	9	view →
THCA	Male	All	−0.522	<.001	9	view →
LIHC	Male	All	+0.716	<.001	8	view →
LUAD	All	II,III,IV	+0.581	<.001	7	view →
READ	Male	All	+1.056	.010	6	view →
CHOL	All	II,III,IV	+1.834	<.001	5	view →
KIRP	All	IV	+0.867	.002	5	view →
LUSC	Male	All	+0.637	<.001	4	view →
ESCA	All	All	+0.958	<.001	3	view →
UCEC	All	All	−0.472	.019	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

POLR1F–STAD

Open the STAD breakdown →