POLR1E

Across TCGA patient cohorts, POLR1E RNA expression is significantly associated with the protein abundance of many other proteins, with 14,546 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible POLR1E-associated proteins across cancer lineages are SMU1, SPOUT1, and SUPT16H. Each is linked with POLR1E in more than 6 cancer types. Because this analysis shows association rather than direction, both POLR1E-to-partner and partner-to-POLR1E results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, POLR1E versus SMU1 in GBM, with a Pearson correlation of 0.43.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (POLR1E→partner) and Y-score (partner→POLR1E) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SMU1 →	+0.214	+0.338	<.001	<.001	3	7
LSCC	SPOUT1 →	+0.425	+0.683	<.001	<.001	3	6
GBM	SUPT16H →	+0.495	+0.501	<.001	<.001	3	6
CCRCC	CTSA →	-0.423	-0.606	<.001	<.001	3	6
GBM	EXOSC7 →	+0.357	+0.622	<.001	<.001	3	6
GBM	EXOSC8 →	+0.401	+0.544	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 14,546 associations by consensus.

POLR1E vs SMU1 — GBM

Explore this scatter interactively →