POLR1E

Across TCGA pan-cancer cohorts, POLR1E RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of POLR1E’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where POLR1E RNA is more highly expressed in tumor relative to normal tissue. In most cancer types POLR1E is over-expressed in tumor, although a few such as UCEC and BRCA show the opposite, repressed pattern.

COAD, KIRC, and KIRP are the cancer types where POLR1E tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in POLR1E RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Male	IV	+1.210	<.001	11	view →
KIRC	Male	All	+0.898	<.001	11	view →
KIRP	All	II,III,IV	+0.857	<.001	8	view →
HNSC	Male	IV	+0.854	<.001	8	view →
UCEC	All	All	−0.846	<.001	6	view →
BRCA	Female	II,III,IV	−0.681	<.001	6	view →
READ	All	All	+0.817	<.001	5	view →
LUSC	Male	II,III,IV	+0.627	<.001	5	view →
KICH	Female	All	−1.156	<.001	3	view →
BLCA	Male	IV	−1.102	.016	2	view →
STAD	Male	II,III,IV	+0.691	.021	2	view →
LUAD	Male	All	+0.333	.005	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

POLR1E–COAD

Open the COAD breakdown →