POLR1E

protein abundance — cross-omics
Cross-omicsPROTEIN-MS → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, POLR1E protein abundance is significantly associated with the RNA expression of many other genes, with 16,629 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible POLR1E-associated genes across cancer lineages are LIG1, POLR1G, and UBE2C. Each is linked with POLR1E in more than 8 cancer types. Because this analysis shows association rather than direction, both POLR1E-to-partner and partner-to-POLR1E results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, POLR1E versus LIG1 in UCEC, with a Pearson correlation of 0.31.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (POLR1E→partner) and Y-score (partner→POLR1E) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
UCECLIG1 →+0.601+0.193<.001.00839
COADPOLR1G →+0.529+0.298<.001<.00139
BRCAUBE2C →+1.427+0.386<.001<.00139
UCECTRAIP →+1.087+0.355<.001<.00139
UCECRPL36A →+0.579+0.318<.001<.00139
LSCCRBL1 →+0.761+0.441<.001<.00139
Each partner links to its Q-omics profile. Showing the 6 strongest of 16,629 associations by consensus.

POLR1E vs LIG1 — UCEC

Per-sample scatter of POLR1E vs LIG1 in UCEC (Pearson r = 0.31).

Explore this scatter interactively →

Exploration