Across TCGA patient cohorts, POLR1D mutation is significantly associated with the RNA expression of many other genes, with 49 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible POLR1D-associated genes across cancer lineages are RNU1-54P, OR5BQ1P, and GUSBP7. Each is linked with POLR1D in more than 1 cancer types. Because this analysis shows association rather than direction, both POLR1D-to-partner and partner-to-POLR1D results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (POLR1D→partner) and Y-score (partner→POLR1D) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	RNU1-54P →	+0.762	+7.731	<.001	.009	3	1
UCEC	OR5BQ1P →	+0.070	+4.736	.002	.003	3	1
UCEC	GUSBP7 →	+0.206	+2.814	.008	.003	3	1
UCEC	MIR6769A →	+0.806	+2.763	.001	.003	3	1
BLCA	OR8J2 →	+0.055	+7.307	<.001	<.001	3	1
BLCA	RN7SL186P →	+0.155	+5.038	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 49 associations by consensus.

Exploration

POLR1D survival (RNA) · tumor vs normal (RNA) · all POLR1D data types