Across TCGA pan-cancer cohorts, POLR1D RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated POLR1D data layer compared with 2 for mutation status and 5 for mass-spec protein.
The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher POLR1D RNA is associated with worse overall survival. In most high-consensus cancer types, elevated POLR1D expression acts as an unfavorable survival marker, although some lineages such as KIRC and UVM show a favorable association.
HNSC, KIRC, and CESC are the cancer types where POLR1D RNA most reproducibly stratifies survival.
RNA survival associations by lineage
Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.