POLQ

Across TCGA patient cohorts, POLQ protein abundance is significantly associated with the protein abundance of many other proteins, with 3,852 significant associations in total. GBM shows the largest number of these associations.

The most reproducible POLQ-associated proteins across cancer lineages are RETREG1_S293, RFX1_S204, and RGL2_S13. Each is linked with POLQ in more than 1 cancer types. Because this analysis shows association rather than direction, both POLQ-to-partner and partner-to-POLQ results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, POLQ versus RETREG1_S293 in GBM, with a Pearson correlation of 0.64.

protein abundance associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (POLQ→partner) and Y-score (partner→POLQ) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	RETREG1_S293 →	+0.881	+0.764	.002	.001	3	1
GBM	RFX1_S204 →	-0.593	-0.532	.001	<.001	3	1
GBM	RGL2_S13 →	-0.714	-0.733	<.001	<.001	3	1
GBM	RGS7BP →	+0.818	+0.587	.001	.001	3	1
GBM	RHOB →	+0.945	+0.686	<.001	.001	3	1
GBM	RIMBP2_S951 →	+2.116	+0.785	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,852 associations by consensus.

POLQ vs RETREG1_S293 — GBM

Explore this scatter interactively →