POLQ

Across TCGA patient cohorts, POLQ mutation is significantly associated with the RNA expression of many other genes, with 6,920 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible POLQ-associated genes across cancer lineages are BCCIP, CCL14, and NUS1. Each is linked with POLQ in more than 6 cancer types. Because this analysis shows association rather than direction, both POLQ-to-partner and partner-to-POLQ results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, BCCIP grouped by POLQ-low versus POLQ-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (POLQ→partner) and Y-score (partner→POLQ) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	BCCIP →	+0.355	+2.011	<.001	.001	3	7
UCEC	CCL14 →	-0.138	-1.663	.009	.003	3	5
LUAD	NUS1 →	+0.516	+3.735	<.001	<.001	3	5
UCEC	HK2 →	+0.482	+1.654	<.001	.001	3	5
LUAD	SGO2 →	+0.638	+2.011	<.001	.001	3	5
LUAD	HMGB2 →	+0.559	+2.427	.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,920 associations by consensus.

BCCIP by POLQ expression — LUAD

Explore this box plot interactively →