POLQ

Across TCGA cell cohorts, POLQ RNA expression is significantly associated with the go_rna of many other GO terms, with 5,047 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible POLQ-associated GO terms across cancer lineages are Negative regulation of cell cycle phase transition, Negative regulation of cell cycle G2/M phase transition, and Microtubule cytoskeleton organization involved in mitosis. Each is linked with POLQ in more than 19 cancer types. Because this analysis shows association rather than direction, both POLQ-to-partner and partner-to-POLQ results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of cell cycle phase transition grouped by POLQ-low versus POLQ-high in BLOOD_Myeloma.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (POLQ→partner) and Y-score (partner→POLQ) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	Negative regulation of cell cycle phase transition →	+0.080	+1.517	<.001	<.001	3	20
SOFT_TISSUE	Negative regulation of cell cycle G2/M phase transition →	+0.090	+1.471	<.001	<.001	3	20
OESOPHAGUS	Microtubule cytoskeleton organization involved in mitosis →	+0.118	+1.142	.009	.003	3	20
SOFT_TISSUE	DNA strand elongation →	+0.175	+1.344	<.001	<.001	3	20
BONE	Replication fork processing →	+0.173	+1.581	<.001	<.001	3	20
BLOOD_Myeloma	DNA integrity checkpoint signaling →	+0.077	+1.208	<.001	<.001	3	20

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,047 associations by consensus.

Negative regulation of cell cycle phase transition by POLQ expression — BLOOD_Myeloma

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