POLQ

Across TCGA cell cohorts, POLQ mutation is significantly associated with the mutation status of many other genes, with 4,562 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible POLQ-associated genes across cancer lineages are SYNE1, TNR, and RALGAPA2. Each is linked with POLQ in more than 6 cancer types. Because this analysis shows association rather than direction, both POLQ-to-partner and partner-to-POLQ results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SYNE1 grouped by POLQ-low versus POLQ-high in BONE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (POLQ→partner) and Y-score (partner→POLQ) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	SYNE1 →	+1.883	+3.688	.005	.005	1	7
LARGE_INTESTINE	TNR →	+2.222	+1.586	<.001	<.001	1	6
LUNG_NSCLC_LUAD	RALGAPA2 →	+4.321	+2.455	<.001	<.001	1	6
LUNG_NSCLC_LUAD	FAT4 →	+1.514	+1.860	.004	.004	1	6
LUNG_NSCLC_LUAD	SNAP91 →	+3.999	+2.299	.005	.005	1	6
SOFT_TISSUE	PCNT →	+3.562	+2.985	.008	.008	1	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,562 associations by consensus.

SYNE1 by POLQ expression — BONE

Explore this box plot interactively →