POLE4

Across TCGA patient cohorts, POLE4 RNA expression is significantly associated with the protein abundance of many other proteins, with 12,393 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible POLE4-associated proteins across cancer lineages are GMPPA, BLNK, and CAD. Each is linked with POLE4 in more than 4 cancer types. Because this analysis shows association rather than direction, both POLE4-to-partner and partner-to-POLE4 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, POLE4 versus GMPPA in LSCC, with a Pearson correlation of -0.56.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (POLE4→partner) and Y-score (partner→POLE4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	GMPPA →	-0.487	-0.672	<.001	<.001	3	5
LSCC	BLNK →	-0.323	-0.307	<.001	<.001	3	4
LSCC	CAD →	+0.219	+0.362	<.001	<.001	3	4
HNSC	FNDC3A_S203 →	-0.454	-0.576	<.001	.009	3	4
LSCC	GNG7 →	-0.521	-0.538	<.001	<.001	3	4
GBM	MCM6_S762 →	+0.897	+0.530	.001	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 12,393 associations by consensus.

POLE4 vs GMPPA — LSCC

Explore this scatter interactively →