POLE4

Across TCGA cell cohorts, POLE4 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,729 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible POLE4-associated GO terms across cancer lineages are Negative regulation of cell cycle checkpoint, Negative regulation of spindle checkpoint, and Negative regulation of mitotic spindle assembly checkpoint signaling. Each is linked with POLE4 in more than 8 cancer types. Because this analysis shows association rather than direction, both POLE4-to-partner and partner-to-POLE4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of cell cycle checkpoint grouped by POLE4-low versus POLE4-high in URINARY_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (POLE4→partner) and Y-score (partner→POLE4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	Negative regulation of cell cycle checkpoint →	+0.139	+0.990	.001	.004	3	9
URINARY_TRACT	Negative regulation of spindle checkpoint →	+0.149	+0.958	<.001	.006	3	8
URINARY_TRACT	Negative regulation of mitotic spindle assembly checkpoint signaling →	+0.149	+0.958	<.001	.006	3	8
LUNG_NSCLC_LUAD	Meiotic cell cycle →	+0.054	+0.718	<.001	.006	3	8
PANCREAS	Pyrimidine nucleoside diphosphate biosynthetic process →	+0.161	+0.786	.001	.009	3	7
UPPER_AERODIGESTIVE_TRACT	Regulation of cell cycle checkpoint →	+0.088	+0.836	.004	.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,729 associations by consensus.

Negative regulation of cell cycle checkpoint by POLE4 expression — URINARY_TRACT

Explore this box plot interactively →