POLD4

Across TCGA patient cohorts, POLD4 protein abundance is significantly associated with the RNA expression of many other genes, with 8,045 significant associations in total. GBM shows the largest number of these associations.

The most reproducible POLD4-associated genes across cancer lineages are B4GALNT4, LSP1, and FAM171A2. Each is linked with POLD4 in more than 2 cancer types. Because this analysis shows association rather than direction, both POLD4-to-partner and partner-to-POLD4 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, POLD4 versus B4GALNT4 in LSCC, with a Pearson correlation of -0.37.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (POLD4→partner) and Y-score (partner→POLD4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	B4GALNT4 →	-1.141	-0.344	<.001	<.001	3	3
GBM	LSP1 →	+1.028	+0.483	.001	.001	3	3
GBM	FAM171A2 →	-1.052	-0.427	<.001	<.001	3	3
OV	LINGO1 →	-1.594	-0.502	<.001	.003	3	3
OV	VPS37D →	-1.009	-0.441	.002	<.001	3	3
GBM	MCF2L →	-1.436	-0.595	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 8,045 associations by consensus.

POLD4 vs B4GALNT4 — LSCC

Explore this scatter interactively →