POLD4

Across TCGA pan-cancer cohorts, POLD4 RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of POLD4’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where POLD4 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types POLD4 is over-expressed in tumor, although a few such as COAD and READ show the opposite, repressed pattern.

KIRC, COAD, and KIRP are the cancer types where POLD4 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in POLD4 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	IV	+1.111	<.001	12	view →
COAD	Female	III,IV	−1.191	<.001	10	view →
KIRP	All	II,III,IV	+0.683	<.001	9	view →
LIHC	Male	II,III,IV	+0.800	<.001	8	view →
READ	All	All	−1.070	<.001	7	view →
BRCA	All	III,IV	+0.832	<.001	6	view →
UCEC	All	All	−0.543	<.001	6	view →
THCA	Male	All	+0.342	.002	6	view →
HNSC	All	All	+0.316	.001	6	view →
LUAD	All	II,III,IV	+0.377	.001	5	view →
CHOL	All	All	+0.902	<.001	3	view →
ESCA	All	All	+0.952	.002	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

POLD4–KIRC

Open the KIRC breakdown →