POLA2

Across TCGA patient cohorts, POLA2 mutation is significantly associated with the RNA expression of many other genes, with 2,977 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible POLA2-associated genes across cancer lineages are RN7SL41P, WASHC3P1, and IGSF22. Each is linked with POLA2 in more than 2 cancer types. Because this analysis shows association rather than direction, both POLA2-to-partner and partner-to-POLA2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SL41P grouped by POLA2-low versus POLA2-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (POLA2→partner) and Y-score (partner→POLA2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	RN7SL41P →	+0.059	+3.495	.002	.003	3	3
STAD	WASHC3P1 →	+0.308	+4.254	<.001	.008	3	3
UCEC	IGSF22 →	-0.337	-2.736	.001	<.001	3	3
UCEC	RNA5SP222 →	+0.197	+3.140	<.001	.004	3	3
UCEC	RNU6-406P →	+0.197	+2.059	.005	.005	3	3
UCEC	RNA5SP411 →	+1.145	+2.015	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,977 associations by consensus.

RN7SL41P by POLA2 expression — SKCM

Explore this box plot interactively →