POLA2

Across TCGA pan-cancer cohorts, POLA2 RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of POLA2’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where POLA2 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types POLA2 is over-expressed in tumor, although a few such as KICH show the opposite, repressed pattern.

HNSC, COAD, and BLCA are the cancer types where POLA2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in POLA2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	III,IV	+1.352	<.001	11	view →
COAD	Female	II,III,IV	+1.170	<.001	11	view →
BLCA	Female	III,IV	+1.491	<.001	10	view →
LIHC	Female	II,III,IV	+1.618	<.001	9	view →
KIRC	Male	IV	+0.634	<.001	9	view →
LUSC	Female	II,III,IV	+1.391	<.001	8	view →
STAD	Male	II,III,IV	+1.110	<.001	8	view →
LUAD	Male	II,III,IV	+0.893	<.001	8	view →
KIRP	All	II,III,IV	+0.546	.003	8	view →
UCEC	All	III,IV	+1.079	<.001	6	view →
BRCA	All	III,IV	+0.953	<.001	6	view →
CHOL	All	All	+1.935	<.001	5	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

POLA2–HNSC

Open the HNSC breakdown →