PNPT1

Across TCGA patient cohorts, PNPT1 mutation is significantly associated with the RNA expression of many other genes, with 1,184 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PNPT1-associated genes across cancer lineages are TRGJP2, RBMY2JP, and HEBP2P1. Each is linked with PNPT1 in more than 2 cancer types. Because this analysis shows association rather than direction, both PNPT1-to-partner and partner-to-PNPT1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TRGJP2 grouped by PNPT1-low versus PNPT1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PNPT1→partner) and Y-score (partner→PNPT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	TRGJP2 →	+0.797	+3.489	<.001	.005	3	3
KIRP	RBMY2JP →	+0.083	+5.528	<.001	.002	3	2
KIRP	HEBP2P1 →	+0.185	+4.273	<.001	.008	3	2
SKCM	USP12PY →	+0.033	+3.525	<.001	.002	3	2
LUAD	RNU6-751P →	+0.271	+6.608	<.001	<.001	3	2
HNSC	RN7SKP171 →	+0.065	+4.221	.003	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,184 associations by consensus.

TRGJP2 by PNPT1 expression — COAD

Explore this box plot interactively →