PNPT1

Across TCGA pan-cancer cohorts, PNPT1 RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of PNPT1’s most consistent transcriptional readouts.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where PNPT1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types PNPT1 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

BLCA, HNSC, and LUAD are the cancer types where PNPT1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PNPT1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BLCA	Female	All	+0.988	<.001	12	view →
HNSC	Male	IV	+1.129	<.001	11	view →
LUAD	Male	II,III,IV	+0.870	<.001	11	view →
THCA	All	All	−0.317	<.001	10	view →
COAD	Female	II,III,IV	+1.250	<.001	9	view →
LIHC	Female	II,III,IV	+0.898	<.001	9	view →
STAD	Male	II,III,IV	+1.297	<.001	8	view →
LUSC	Male	II,III,IV	+1.085	<.001	7	view →
KICH	Female	II,III,IV	−1.484	<.001	6	view →
UCEC	All	III,IV	+0.679	.023	6	view →
READ	All	All	+0.915	.001	5	view →
BRCA	All	II,III,IV	+0.379	<.001	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

PNPT1–BLCA

Open the BLCA breakdown →