PNPLA8

Across TCGA patient cohorts, PNPLA8 mutation is significantly associated with the RNA expression of many other genes, with 4,152 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PNPLA8-associated genes across cancer lineages are RN7SKP214, RNA5SP86, and RNU2-36P. Each is linked with PNPLA8 in more than 1 cancer types. Because this analysis shows association rather than direction, both PNPLA8-to-partner and partner-to-PNPLA8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SKP214 grouped by PNPLA8-low versus PNPLA8-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PNPLA8→partner) and Y-score (partner→PNPLA8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	RN7SKP214 →	+0.676	+2.734	<.001	.006	3	2
COAD	RNA5SP86 →	+0.640	+4.335	<.001	.005	3	2
COAD	RNU2-36P →	+0.808	+3.602	<.001	.003	3	2
COAD	RN7SKP188 →	+0.151	+4.927	<.001	.002	3	2
UCEC	C9orf50 →	-0.471	-4.000	.001	<.001	3	2
UCEC	GEMIN4 →	+0.572	+3.828	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,152 associations by consensus.

RN7SKP214 by PNPLA8 expression — COAD

Explore this box plot interactively →