PNPLA8

Across TCGA pan-cancer cohorts, PNPLA8 RNA differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of PNPLA8’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where PNPLA8 RNA is repressed in tumor relative to normal tissue. In most cancer types PNPLA8 is over-expressed in tumor, although a few such as THCA and KIRC show the opposite, repressed pattern.

THCA, KIRC, and KIRP are the cancer types where PNPLA8 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PNPLA8 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	III,IV	−0.892	<.001	10	view →
KIRC	Male	II,III,IV	−0.567	<.001	10	view →
KIRP	Male	All	−0.482	.006	6	view →
ESCA	All	All	+0.761	.002	3	view →
UCEC	All	All	−0.426	.027	2	view →
HNSC	All	III,IV	+0.457	.019	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

PNPLA8–THCA

Open the THCA breakdown →