PNPLA7

Across TCGA cell cohorts, PNPLA7 mutation is significantly associated with the RNA expression of many other genes, with 1,171 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PNPLA7-associated genes across cancer lineages are NRSN1, LRRC3B, and TRIM42. Each is linked with PNPLA7 in more than 1 cancer types. Because this analysis shows association rather than direction, both PNPLA7-to-partner and partner-to-PNPLA7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NRSN1 grouped by PNPLA7-low versus PNPLA7-high in OESOPHAGUS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PNPLA7→partner) and Y-score (partner→PNPLA7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	NRSN1 →	+0.029	+3.584	.001	.008	3	1
OESOPHAGUS	LRRC3B →	+0.045	+3.392	.005	.007	3	1
LUNG_SCLC	TRIM42 →	+0.019	+3.584	<.001	.003	3	1
LUNG_SCLC	FCAMR →	+0.034	+3.624	.003	.005	2	2
LUNG_SCLC	FAM170A →	+0.066	+3.624	<.001	.005	3	1
LUNG_SCLC	PAGE3 →	+0.048	+3.232	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,171 associations by consensus.

NRSN1 by PNPLA7 expression — OESOPHAGUS

Explore this box plot interactively →