PNPLA7

Across TCGA pan-cancer cohorts, PNPLA7 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of PNPLA7’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where PNPLA7 RNA is repressed in tumor relative to normal tissue. In most cancer types PNPLA7 is over-expressed in tumor, although a few such as HNSC and LUAD show the opposite, repressed pattern.

HNSC, LUAD, and LIHC are the cancer types where PNPLA7 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PNPLA7 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	All	−0.907	<.001	12	view →
LUAD	Male	II,III,IV	−1.030	<.001	9	view →
LIHC	Male	II,III,IV	−0.895	<.001	9	view →
THCA	All	II,III,IV	−0.690	<.001	9	view →
KIRC	Female	All	+0.685	<.001	9	view →
LUSC	Female	II,III,IV	−1.657	<.001	8	view →
BLCA	Male	IV	−1.515	<.001	8	view →
UCEC	All	II,III,IV	−1.280	<.001	6	view →
BRCA	All	II,III,IV	−1.257	<.001	6	view →
READ	Male	All	−1.153	.004	5	view →
COAD	All	II,III,IV	−0.404	.005	4	view →
PRAD	All	All	+0.581	.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

PNPLA7–HNSC

Open the HNSC breakdown →