PNPLA4

Across TCGA patient cohorts, PNPLA4 mutation is significantly associated with the RNA expression of many other genes, with 670 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PNPLA4-associated genes across cancer lineages are RNU6-918P, IFNA6, and RN7SL196P. Each is linked with PNPLA4 in more than 1 cancer types. Because this analysis shows association rather than direction, both PNPLA4-to-partner and partner-to-PNPLA4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-918P grouped by PNPLA4-low versus PNPLA4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PNPLA4→partner) and Y-score (partner→PNPLA4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNU6-918P →	+0.311	+3.042	<.001	<.001	3	2
SKCM	IFNA6 →	+0.070	+5.970	<.001	.002	3	1
LUSC	RN7SL196P →	+0.124	+7.924	<.001	.008	3	1
UCEC	H2AC4 →	+0.561	+3.625	.002	.001	3	1
UCEC	NR2E3 →	-0.468	-2.289	.009	.006	3	1
UCEC	LINC01727 →	+0.092	+2.695	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 670 associations by consensus.

RNU6-918P by PNPLA4 expression — UCEC

Explore this box plot interactively →