PNPLA4

Across TCGA pan-cancer cohorts, PNPLA4 RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of PNPLA4’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where PNPLA4 RNA is repressed in tumor relative to normal tissue. In most cancer types PNPLA4 is over-expressed in tumor, although a few such as THCA and KIRC show the opposite, repressed pattern.

THCA, KIRC, and KIRP are the cancer types where PNPLA4 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PNPLA4 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	IV	−1.216	<.001	11	view →
KIRC	Female	All	−0.615	<.001	11	view →
KIRP	All	All	−0.581	<.001	5	view →
UCEC	All	All	−1.000	.001	4	view →
KICH	Female	All	−0.765	.004	3	view →
READ	Male	All	+0.666	.026	3	view →
COAD	Male	All	+0.428	.011	3	view →
LIHC	Male	All	+0.355	<.001	3	view →
LUSC	Male	All	+0.431	.002	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

PNPLA4–THCA

Open the THCA breakdown →