PNMT

Across TCGA patient cohorts, PNMT protein abundance is significantly associated with the RNA expression of many other genes, with 1,635 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PNMT-associated genes across cancer lineages are SNPH, IFFO1, and TCAP. Each is linked with PNMT in more than 1 cancer types. Because this analysis shows association rather than direction, both PNMT-to-partner and partner-to-PNMT results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PNMT versus SNPH in UCEC, with a Pearson correlation of 0.45.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PNMT→partner) and Y-score (partner→PNMT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SNPH →	+1.080	+1.105	<.001	.001	3	2
BRCA	IFFO1 →	+0.678	+1.013	.001	.003	3	2
UCEC	TCAP →	+1.728	+1.065	.004	.008	3	2
UCEC	HNRNPA1P34 →	+1.010	+1.028	.004	.005	3	2
UCEC	SETP21 →	+1.766	+1.305	<.001	<.001	3	2
BRCA	TRMT112P3 →	+0.356	+1.296	.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,635 associations by consensus.

PNMT vs SNPH — UCEC

Explore this scatter interactively →