PNMT

Across TCGA pan-cancer cohorts, PNMT RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of PNMT’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where PNMT RNA is repressed in tumor relative to normal tissue. In most cancer types PNMT is over-expressed in tumor, although a few such as KIRC and KIRP show the opposite, repressed pattern.

KIRC, THCA, and KIRP are the cancer types where PNMT tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PNMT RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	II,III,IV	−1.287	<.001	12	view →
THCA	Female	II,III,IV	+1.439	<.001	9	view →
KIRP	Male	All	−1.435	<.001	9	view →
LUAD	Male	All	−1.065	<.001	8	view →
LUSC	Female	All	−1.032	<.001	5	view →
UCEC	All	II,III,IV	−1.070	.040	4	view →
CHOL	All	II,III,IV	+2.155	.021	2	view →
PRAD	All	All	−2.114	<.001	2	view →
PAAD	All	All	+1.215	.039	2	view →
KICH	All	All	−1.099	.002	2	view →
LUAD	All	IV	+0.845	.013	2	view →
BLCA	All	III,IV	+0.910	.037	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

PNMT–KIRC

Open the KIRC breakdown →