Q-omics provides the consensus-scored SETP21 profile across patient tissues and cancer cell-line models. SETP21 expression is associated with patient survival in 21 of 34 cancer types, with the highest sampling consensus in ACC. Among the 18 cancer types available for tumor–normal comparison, SETP21 is differentially expressed in 7, with the highest sampling consensus in COAD. Additionally, SETP21 RNA expression shows 12,319 significant protein co-abundance associations, with the highest sampling consensus in GBM. Together, these results highlight ACC, COAD, and GBM as cancer lineages where SETP21 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for SETP21 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes SETP21 survival associations across molecular data types. SETP21 RNA expression shows survival associations in the most cancer types (21). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible SETP21 RNA expression–survival associations across cancer types. High SETP21 expression shows unfavorable associations in ACC, LIHC, LUSC, KIRP and MESO, but favorable associations in BLCA. The ACC Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify ACC as the clearest survival context for SETP21 RNA expression.
This table summarizes SETP21 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 7. The strongest signals are observed in COAD for RNA.
This table ranks reproducible tumor–normal expression differences for SETP21. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. SETP21 shows higher tumor expression in COAD, LIHC, HNSC, LUSC, BRCA and PRAD. The COAD box plot shows higher SETP21 RNA expression in tumor versus normal tissue (log2 FC = +0.101, t-test p = .001).
This table shows molecular features associated with SETP21 in patient tissues and cancer cell lines. In patient samples, SETP21 shows the broadest associations at the RNA and protein expression levels, with GBM recurring as the lineage with the largest associated feature set.
