PNMT

Across TCGA patient cohorts, PNMT mutation is significantly associated with the RNA expression of many other genes, with 414 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PNMT-associated genes across cancer lineages are RIMBP3B, MIR8082, and C9orf135-DT. Each is linked with PNMT in more than 1 cancer types. Because this analysis shows association rather than direction, both PNMT-to-partner and partner-to-PNMT results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RIMBP3B grouped by PNMT-low versus PNMT-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PNMT→partner) and Y-score (partner→PNMT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RIMBP3B →	+0.022	+2.926	<.001	.001	3	1
UCEC	MIR8082 →	+0.533	+2.754	<.001	.007	3	1
COAD	C9orf135-DT →	+0.038	+4.665	.009	.001	3	1
COAD	BPY2DP →	+0.236	+5.824	<.001	.001	3	1
SKCM	LINC02250 →	+0.028	+3.632	<.001	.001	3	1
SKCM	LINC02659 →	+0.102	+3.993	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 414 associations by consensus.

RIMBP3B by PNMT expression — UCEC

Explore this box plot interactively →