Across TCGA patient cohorts, PNMA8B protein abundance is significantly associated with the RNA expression of many other genes, with 9,465 significant associations in total. GBM shows the largest number of these associations.

The most reproducible PNMA8B-associated genes across cancer lineages are CNKSR2, HEYL, and TUB. Each is linked with PNMA8B in more than 4 cancer types. Because this analysis shows association rather than direction, both PNMA8B-to-partner and partner-to-PNMA8B results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PNMA8B→partner) and Y-score (partner→PNMA8B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	CNKSR2 →	+0.541	+0.323	.004	.003	3	5
UCEC	HEYL →	+1.268	+0.698	<.001	.001	3	5
UCEC	TUB →	+1.239	+0.523	<.001	.001	3	5
UCEC	KLHDC1 →	+0.997	+0.844	<.001	<.001	3	5
UCEC	SLC22A17 →	+1.038	+0.677	<.001	<.001	3	5
UCEC	DACT3 →	+1.120	+0.829	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 9,465 associations by consensus.

Exploration

PNMA8B survival (RNA) · tumor vs normal (RNA) · all PNMA8B data types