Across TCGA patient cohorts, PNMA8B mutation is significantly associated with the RNA expression of many other genes, with 2,366 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PNMA8B-associated genes across cancer lineages are GAS2L1, SNRPD3, and GCAT. Each is linked with PNMA8B in more than 3 cancer types. Because this analysis shows association rather than direction, both PNMA8B-to-partner and partner-to-PNMA8B results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PNMA8B→partner) and Y-score (partner→PNMA8B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	GAS2L1 →	+0.750	+3.595	<.001	.001	3	3
UCEC	SNRPD3 →	+0.303	+2.263	.003	<.001	3	3
UCEC	GCAT →	+0.522	+2.661	.003	.004	3	3
UCEC	LMF2 →	+0.428	+4.210	.001	<.001	3	3
UCEC	POLE2 →	+0.491	+3.928	.001	<.001	3	3
UCEC	C1QBP →	+0.465	+1.938	.002	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,366 associations by consensus.

Exploration

PNMA8B survival (RNA) · tumor vs normal (RNA) · all PNMA8B data types