Across TCGA patient cohorts, PNMA8B mutation is significantly associated with the total protein of many other genes, with 32 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PNMA8B-associated genes across cancer lineages are Lck, MIG-6, and FOXO3a. Each is linked with PNMA8B in more than 1 cancer types. Because this analysis shows association rather than direction, both PNMA8B-to-partner and partner-to-PNMA8B results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PNMA8B→partner) and Y-score (partner→PNMA8B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Lck →	+0.483	+2.610	<.001	.005	3	2
COAD	MIG-6 →	+0.085	+3.012	.041	.018	3	2
UCEC	FOXO3a →	-0.099	-1.687	.005	.040	3	2
UCEC	JNK_pT183_Y185 →	-0.167	-1.649	.005	.011	3	2
UCEC	MSH2 →	-0.361	-2.880	<.001	.001	3	2
UCEC	Cyclin-B1 →	+0.515	+3.321	.009	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

Exploration

PNMA8B survival (RNA) · tumor vs normal (RNA) · all PNMA8B data types