PNMA8A

Across TCGA patient cohorts, PNMA8A mutation is significantly associated with the RNA expression of many other genes, with 4,169 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PNMA8A-associated genes across cancer lineages are PFN1, YWHAE, and LAMTOR1. Each is linked with PNMA8A in more than 2 cancer types. Because this analysis shows association rather than direction, both PNMA8A-to-partner and partner-to-PNMA8A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PFN1 grouped by PNMA8A-low versus PNMA8A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PNMA8A→partner) and Y-score (partner→PNMA8A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PFN1 →	+0.388	+3.467	.007	.002	3	3
UCEC	YWHAE →	+0.510	+4.032	<.001	<.001	3	3
UCEC	LAMTOR1 →	+0.376	+4.010	.005	<.001	3	2
UCEC	C18orf25 →	+0.618	+4.010	<.001	<.001	3	2
UCEC	HOMER1 →	+0.979	+2.906	<.001	.002	3	2
UCEC	CCSAP →	+0.820	+2.928	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,169 associations by consensus.

PFN1 by PNMA8A expression — UCEC

Explore this box plot interactively →