PNMA8A

Across TCGA pan-cancer cohorts, PNMA8A RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated PNMA8A data layer compared with 5 for mutation status and 3 for mass-spec protein.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher PNMA8A RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated PNMA8A expression acts as an unfavorable survival marker, although some lineages such as LUAD and COAD show a favorable association.

LUAD, KIRC, and COAD are the cancer types where PNMA8A RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Median	All	0.849	0.674	<.001	77	view →
KIRC	DFS	Median	All	0.762	0.838	.006	35	view →
COAD	OS	Tertile	IV	0.889	0.255	.003	22	view →
GBM	DFS	Tertile	All	0.443	0.205	.003	21	view →
UCEC	DFS	Tertile	IV	0.893	0.367	.021	20	view →
CESC	OS	Tertile	IV	0.809	0.382	.016	18	view →
STAD	OS	Median	All	0.522	0.644	.015	17	view →
SCLC	DFS	Tertile	III,IV	0.671	0.202	.002	16	view →
BLCA	OS	Median	All	0.548	0.669	.003	16	view →
LAML	DFS	Quartile	All	0.297	0.724	.031	10	view →
SARC	OS	Median	All	0.667	0.852	.004	10	view →
ACC	DFS	Tertile	IV	0.487	0.048	.024	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

PNMA8A–LUAD (DFS)

Open the LUAD breakdown →