PNMA8A

Across TCGA cell cohorts, PNMA8A mutation is significantly associated with the RNA expression of many other genes, with 13 significant associations in total. URINARY_TRACT shows the largest number of these associations.

The most reproducible PNMA8A-associated genes across cancer lineages are KCNK10, HTR3D, and MBD3L2B. Each is linked with PNMA8A in more than 1 cancer types. Because this analysis shows association rather than direction, both PNMA8A-to-partner and partner-to-PNMA8A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KCNK10 grouped by PNMA8A-low versus PNMA8A-high in URINARY_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PNMA8A→partner) and Y-score (partner→PNMA8A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	KCNK10 →	+0.507	+3.836	<.001	.004	3	1
URINARY_TRACT	HTR3D →	+0.026	+4.044	<.001	.001	3	1
URINARY_TRACT	MBD3L2B →	+0.036	+4.044	<.001	.001	3	1
URINARY_TRACT	DCDC2C →	+0.110	+4.632	.001	<.001	3	1
URINARY_TRACT	NLRP2B →	+0.024	+4.050	.001	.002	3	1
BLOOD_Leukemia	DEFA1B →	+2.098	+4.922	.003	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

KCNK10 by PNMA8A expression — URINARY_TRACT

Explore this box plot interactively →