Across TCGA patient cohorts, PMS2CL mutation is significantly associated with the RNA expression of many other genes, with 3,683 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PMS2CL-associated genes across cancer lineages are MESTP2, RN7SL275P, and RN7SL248P. Each is linked with PMS2CL in more than 1 cancer types. Because this analysis shows association rather than direction, both PMS2CL-to-partner and partner-to-PMS2CL results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PMS2CL→partner) and Y-score (partner→PMS2CL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIHC	MESTP2 →	+0.062	+6.902	<.001	<.001	3	2
CESC	RN7SL275P →	+0.203	+4.653	<.001	.004	3	2
UCEC	RN7SL248P →	+0.056	+3.059	<.001	.005	3	2
UCEC	RNF19BPY →	+0.015	+3.738	<.001	.009	3	2
UCEC	RN7SKP132 →	+0.079	+3.214	<.001	.004	3	2
LIHC	RNU6-899P →	+0.731	+5.878	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,683 associations by consensus.

Exploration

PMS2CL survival (RNA) · tumor vs normal (RNA) · all PMS2CL data types