PMPCB

Across TCGA patient cohorts, PMPCB mutation is significantly associated with the RNA expression of many other genes, with 2,102 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PMPCB-associated genes across cancer lineages are CD24P1, HINT1, and HPF1. Each is linked with PMPCB in more than 1 cancer types. Because this analysis shows association rather than direction, both PMPCB-to-partner and partner-to-PMPCB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CD24P1 grouped by PMPCB-low versus PMPCB-high in LIHC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PMPCB→partner) and Y-score (partner→PMPCB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIHC	CD24P1 →	+0.154	+4.293	<.001	.009	3	2
UCEC	HINT1 →	+0.523	+3.213	<.001	<.001	3	2
UCEC	HPF1 →	+0.485	+2.254	.001	.005	3	2
UCEC	DGCR11 →	+0.345	+4.008	.008	<.001	3	2
LIHC	MIR4479 →	+0.742	+4.689	<.001	.001	3	2
UCEC	SLC52A3 →	-0.872	-2.689	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,102 associations by consensus.

CD24P1 by PMPCB expression — LIHC

Explore this box plot interactively →