PMPCB

Across TCGA pan-cancer cohorts, PMPCB RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of PMPCB’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where PMPCB RNA is more highly expressed in tumor relative to normal tissue. In most cancer types PMPCB is over-expressed in tumor, although a few such as BRCA show the opposite, repressed pattern.

COAD, LUAD, and LIHC are the cancer types where PMPCB tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PMPCB RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	All	II,III,IV	+0.518	<.001	8	view →
LUAD	Male	All	+0.512	<.001	8	view →
LIHC	Male	All	+0.490	<.001	8	view →
KICH	Male	II,III,IV	+0.711	<.001	5	view →
CHOL	All	All	+0.655	<.001	5	view →
ESCA	All	All	+0.671	<.001	4	view →
READ	All	II,III,IV	+0.375	.001	4	view →
LUSC	Male	All	+0.297	<.001	4	view →
STAD	All	II,III,IV	+0.397	.004	3	view →
HNSC	All	III,IV	+0.421	.007	2	view →
PRAD	All	All	+0.262	.006	2	view →
BRCA	Female	All	−0.137	.016	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

PMPCB–COAD

Open the COAD breakdown →