PMP22

Across TCGA patient cohorts, PMP22 mutation is significantly associated with the RNA expression of many other genes, with 2,434 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PMP22-associated genes across cancer lineages are TAAR2, RNA5SP389, and RNU6-1149P. Each is linked with PMP22 in more than 1 cancer types. Because this analysis shows association rather than direction, both PMP22-to-partner and partner-to-PMP22 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TAAR2 grouped by PMP22-low versus PMP22-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PMP22→partner) and Y-score (partner→PMP22) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	TAAR2 →	+0.023	+4.342	<.001	.007	3	2
UCEC	RNA5SP389 →	+0.666	+2.353	<.001	.004	3	2
UCEC	RNU6-1149P →	+0.261	+2.613	<.001	<.001	3	2
UCEC	PRAMEF13 →	+0.015	+2.868	.005	.009	3	2
CESC	RN7SL741P →	+0.064	+5.164	<.001	.002	3	2
CESC	ZNF646P1 →	+0.019	+4.144	.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,434 associations by consensus.

TAAR2 by PMP22 expression — CESC

Explore this box plot interactively →