Across TCGA patient cohorts, PMEL mutation is significantly associated with the RNA expression of many other genes, with 1,226 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PMEL-associated genes across cancer lineages are RNA5SP436, RNA5SP416, and RNU7-12P. Each is linked with PMEL in more than 2 cancer types. Because this analysis shows association rather than direction, both PMEL-to-partner and partner-to-PMEL results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PMEL→partner) and Y-score (partner→PMEL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNA5SP436 →	+0.232	+2.615	<.001	.004	3	3
UCEC	RNA5SP416 →	+0.564	+1.944	<.001	.005	3	3
BRCA	RNU7-12P →	+0.510	+3.726	<.001	.001	3	3
BRCA	TFAMP2 →	+0.021	+4.054	.006	.009	3	2
LGG	SNX3P1Y →	+0.193	+5.047	<.001	.003	3	2
LUAD	IGHVII-28-1 →	+1.524	+5.377	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,226 associations by consensus.

Exploration

PMEL survival (RNA) · tumor vs normal (RNA) · all PMEL data types