PLXND1

Across TCGA patient cohorts, PLXND1 mutation is significantly associated with the RNA expression of many other genes, with 7,308 significant associations in total. STAD shows the largest number of these associations.

The most reproducible PLXND1-associated genes across cancer lineages are CHAF1B, TIPIN, and FCER1A. Each is linked with PLXND1 in more than 5 cancer types. Because this analysis shows association rather than direction, both PLXND1-to-partner and partner-to-PLXND1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CHAF1B grouped by PLXND1-low versus PLXND1-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLXND1→partner) and Y-score (partner→PLXND1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	CHAF1B →	+0.641	+4.000	<.001	<.001	3	6
UCEC	TIPIN →	+0.464	+1.691	<.001	<.001	3	5
STAD	FCER1A →	-0.862	-3.442	.008	.004	3	5
STAD	SENP3-EIF4A1 →	+0.246	+3.090	<.001	<.001	3	5
STAD	TMEM135 →	+0.515	+4.016	<.001	<.001	3	5
STAD	STOML2 →	+0.539	+4.000	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,308 associations by consensus.

CHAF1B by PLXND1 expression — STAD

Explore this box plot interactively →